Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase

Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase

Shiloh MU;MacMicking JD;Nicholson S;Brause JE;Potter S;Marino M;Fang F;Dinauer M;Nathan C;;
immunity 1999 Vol. 10 pp. -
260
mu1999immunityphenotype

Abstract

The two genetically established antimicrobial mechanisms of macrophages are production of reactive oxygen intermediates by phagocyte oxidase (phox) and reactive nitrogen intermediates by inducible nitric oxide synthase (NOS2). Mice doubly deficient in both enzymes (gp91(phox-/-)/NOS2(-/-)) formed ma …

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