The advanced glycation end product pentosidine correlates to IL-6 and other relevant inflammatory markers in rheumatoid arthritis
Hein GE;Köhler M;Oelzner P;Stein G;Franke S;;
Rheumatology international2005Vol. 26pp. -
400
ge2005rheumatologythe
Abstract
The binding of AGE on cell receptors induces activation of nuclear factor kappa B, resulting in enhanced synthesis of proinflammatory cytokines. Moreover, AGE generation may also lead to the formation of new, immunologically relevant epitopes at synovial proteins. Both mechanisms could contribute to …