Interaction of the Indian, Arabian and Eurasian tectonic plates has resulted in the formation of major active fault systems in South Asia. Compression along the tectonic boundaries results in thrust or reverse type of faulting and zones of crustal deformation characterized by high seismic activity and continuing Orogenesis. The more intense seismic activity occurs near regions of thrust faulting which is developing at the Himalayan foothills. In northern Pakistan, the Hindu Kush Mountains converge with the Karakoram Range to form a part of the Himalayan mountain system. Northern, western as well as southern Pakistan, Kashmir and northern India and Afghanistan are along such zones of high seismic activity. In Pakistan, most of the earthquakes occur in the north and western regions along the boundary of the Indian tectonic plate with the Iranian and Afghan micro-plates. The active zone extends from the Makran region in the southwest to the Hazara-Kashmir syntaxial bend in the north. Southwest Pakistan is vulnerable to both earthquake and tsunami hazards. In 2005, earthquakes devastated northern Pakistan and Kashmir and severely affected the cities of Muzaffarabad, Islamadad and Rawalpindi, causing severe destruction to the infrastructure of the northern region. A major earthquake along an extensive transform fault system in 1935 destroyed the city Quetta and the adjoining region. A major earthquake along the northern Arabian sea in 1945 generated a very destructive tsunami along the coasts of Baluchistan and Sindh Provinces. The region near Karachi is vulnerable as it is located near four major faults where destructive earthquakes and tsunamis have occurred in the past. Given Pakistan’s vulnerability and extensive infrastructure development in recent years, the present study reviews briefly the earthquake and tsunami risk factors and assesses the impact that such disasters can have on the country’s critical infrastructure - which includes nuclear facilities and power reactors.