Efficacy of Vedolizumab Induction and Maintenance Therapy in Patients With Ulcerative Colitis, Regardless of Prior Exposure to Tumor Necrosis Factor Antagonists
Abstract
Vedolizumab demonstrated significantly greater efficacy as induction and maintenance therapy for UC than placebo in patients naive to TNF antagonists and patients with TNF antagonist failure. There were numerically greater treatment differences at Week 6 among patients receiving vedolizumab who were …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
treatment outcome
research support
non-u.s. gov't
adult
female
male
middle aged
randomized controlled trials as topic
Antibodies
Monoclonal
Brian G Feagan
Humanized / therapeutic use*
Colitis
Ulcerative / drug therapy*
Gastrointestinal Agents / therapeutic use*
placebos / administration & dosage
pmid:27639327
doi:10.1016/j.cgh.2016.08.044
david t rubin
michael smyth
clinical trials
phase iii as topic
induction chemotherapy / methods
maintenance chemotherapy / methods
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115945
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