Though inland ships account for a small portion of the total global CO2 emissions from shipping, from the individual country’s economic and environmental perspective, this is very important. To reduce CO2 emissions from sea-going ships by increasing energy efficiency, the International Maritime Organization (IMO) adopted a generalized Energy Efficiency Design Index (EEDI) in 2011. However, due to the variation in environmental, geographic and economic conditions, a generalized EEDI cannot be established in a similar fashion to that established by IMO. Shallow and restricted water effects, different fuel qualities (to reduce operational cost), increase in engine power requirements, reduction in carrying capacity, cargo availability, etc. make the EEDI by IMO inadequate for inland waterways. Therefore, an EEDI formulation based on revised parameters has been proposed for the inland ships in Bangladesh. This paper focuses on the possibility of CO2 emissions reduction from inland oil tankers in Bangladesh by implementing the revised EEDI formulation (henceforth denoted as EEDIINLAND). A sensitivity analysis was performed for the different ship design parameters of those oil tankers. Based on the analysis, suggestions were made on how to design inland oil tankers in Bangladesh using the revised EEDI formulation for reducing CO2 from the current level without any major cost involvement. Keeping the same speed and capacity, the vessels were redesigned based on those suggestions. The Computational Fluid Dynamics (CFD) analysis of those redesigned vessels using ‘Shipflow’ showed a reduction in CO2 emissions through increasing EEDIINLAND by 7.54–13.65%.