Inflammation-restricted anti-inflammatory activities of a N-acylethanolamine acid amidase (NAAA) inhibitor F215
Li Y;Zhou P;Chen H;Chen Q;Kuang X;Lu C;Ren J;Qiu Y;;
pharmacological research2018Vol. 132pp. -
372
y2018pharmacologicalinflammation-restricted
Abstract
N-Acylethanolamine acid amidase (NAAA) is a cysteine enzyme that catalyzes the hydrolysis of palmitoylethanolamide (PEA). Pharmacological blockage of NAAA elevates PEA levels and exerts powerful anti-inflammatory activities. We have recently identified a highly potent NAAA inhibitor F215. Here, we d …